AICAR

Potential Benefits of AICAR Peptide

• AMPK Activation: AICAR, short for 5-Aminoimidazole-4-carboxamide ribonucleotide, is known to stimulate AMP-activated protein kinase (AMPK) activity. AMPK is a key regulator of cellular energy homeostasis, which makes AICAR beneficial in metabolic regulation [1].
• Enhanced Endurance: Studies have shown that AICAR peptide can enhance endurance in mice by transforming fast-twitch muscle fibers into the more energy-efficient, fat-burning, slow-twitch type [2].
• Cardioprotection: AICAR has demonstrated cardioprotective properties. It has been found to limit infarct size during ischemia and improve post-ischemic heart function [3].
• Neuroprotection: Research suggests that AICAR has potential neuroprotective effects. It may mitigate neuronal damage after incidents such as stroke or spinal cord injury [4].
• Anti-Diabetic Effects: AICAR peptide has been shown to improve insulin sensitivity, presenting potential benefits for managing type 2 diabetes [5].
• Cancer Therapy Potential: While more research is needed, studies suggest AICAR might have potential in cancer therapy due its ability to inhibit cell proliferation and induce apoptosis in certain cancer cell lines [6].
• Inflammation Modulation: AICAR has been observed to exert anti-inflammatory effects, which may have significant implications in the treatment of chronic inflammatory diseases [7].

References

1. https://www.researchgate.net/ publication/6128312
2. Narkar VA, Downes M, Yu RT, et al. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008;134(3):405-415. doi:10.1016/j.cell.2008.06.051
3. Yin T, Sandhu G, Wolfgang CD, et al. Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney. J Biol Chem. 1997;272(32):19943-19950. doi:10.1074/jbc.272.32.19943
4. https://pubmed.ncbi.nlm.nih.gov/22198598/
5. https://pubmed.ncbi.nlm.nih.gov/12351423/
6. https://pubmed.ncbi.nlm.nih.gov/17638885/
7. https://pubmed.ncbi.nlm.nih.gov/19050283/

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